Frequentist tests of association for imputed genotypes
نویسنده
چکیده
Servin and Matthews [17] proposed looking for associations between phenotypes and both typed and untyped SNPs, by using a reference panel to infer the alleles of the untyped SNPs. Since then, a number of GWA studies have reported p-values for both typed and untyped SNPs. However, results of Almeida et al [1] indicate that using imputed genotype data can lead to increased type I error. We discuss possible causes of inflated type I error from using imputed data and propose methodology designed for conducting GWAS studies with imputed genotypes.
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تاریخ انتشار 2013